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Normal and abnormal sexual differentiation 

Normal and abnormal sexual differentiation
Normal and abnormal sexual differentiation

I.A. Hughes



Sex chromosome disorders of sex development (DSD)—SOX3 gene can be involved in testis determination and explains the paradox of testis development in some XX males lacking SRY. Description of newly discovered genes that explain the molecular basis of XY gonadal dysgenesis, including CBX2 and MAPK31.

Clinical features associated with variations in the androgen receptor.

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date: 28 September 2021

Human sex development follows an orderly sequence of embryological events coordinated by a cascade of gene expression and hormone production in a time- and concentration-dependent manner. Underpinning the entire process of fetal sex development is the simple mantra: sex chromosomes (XX or XY) dictate the gonadotype (ovary or testis), which then dictates the somatotype (female or male phenotype)....

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