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The thyroid gland and disorders of thyroid function 

The thyroid gland and disorders of thyroid function
Chapter:
The thyroid gland and disorders of thyroid function
Author(s):

Anthony P. Weetman

DOI:
10.1093/med/9780199204854.003.1304_update_002

July 30, 2015: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Update:

Chapter reviewed July 2012—no significant alteration required.

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date: 13 August 2020

The iodine-containing thyroid hormones triodothyronine (T3) and thyroxine (T4) have diverse effects on metabolism and are essential for normal development, particularly of the fetal brain. The active principle, T3, binds to nuclear receptor isoforms and serves as a transcriptional regulatory factor, thus explaining the protean actions....

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