Show Summary Details
Page of

The acute phase response and C-reactive protein 

The acute phase response and C-reactive protein
The acute phase response and C-reactive protein

M.B. Pepys


February 27, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.


Discussion of lack of utility of CRP measurements in risk assessment for cardiovascular disease.

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 28 September 2021

The acute phase response—trauma, tissue necrosis, infection, inflammation, and malignant neoplasia induce a complex series of nonspecific systemic, physiological, and metabolic responses including fever, leucocytosis, catabolism of muscle proteins, greatly increased de novo synthesis and secretion of a number of ‘acute phase’ plasma proteins, and decreased synthesis of albumin, transthyretin, and high- and low-density lipoproteins. The altered plasma protein concentration profile is called the acute phase response. All endothermic animals mount a similar response, suggesting that it may have survival value, and increased availability of proteinase inhibitors, complement, clotting, and transport proteins presumably enhances host resistance, minimizes tissue injury, and promotes regeneration and repair....

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.