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Strongyloidiasis, hookworm, and other gut strongyloid nematodes 

Strongyloidiasis, hookworm, and other gut strongyloid nematodes
Strongyloidiasis, hookworm, and other gut strongyloid nematodes

Michael Brown


August 28, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.


Strongyloides diagnosis—development of real-time PCR assays; treatment—two doses of ivermectin may be better than one.

Hookworm control programmes—systematic review published.

Hookworm treatment—single-dose mebendazole less effective than albendazole.

Soil-transmitted helminth treatment in schoolchildren—failure to achieve WHO’s 2010 target.

Hookworm vaccine—results of phase I studies.

Hookworm immune modulation—maternal helminth infections may reduce neonatal atopic disease.

Oesophagostomiasis—impact of mass treatment campaigns.

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date: 16 October 2021

Strongyloides stercoralis and hookworms are common soil-transmitted nematodes in tropical and subtropical regions. After the organisms penetrate exposed skin, most infections are asymptomatic, but heavy infections can result in significant morbidity.

The roundworm S. stercoralis infects an estimated 30 million to 100 million people. Clinical manifestations include: (1) skin—often the only clinical manifestation, commonly in the form of larva currens, a serpiginous, pruritic, erythematous eruption at the site of migrating larvae; (2) lungs—cough and tracheal irritation; less commonly wheeze; patchy infiltrates on chest radiography with eosinophilia; (3) intestinal—epigastric pain and diarrhoea; (4) ...

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