- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 7.1 Pathogenic microorganisms and the host
- 7.2 The patient with suspected infection
- 7.3 Immunization
- 7.4 Travel and expedition medicine
- 7.5 Viruses
- 7.6 Bacteria
- 7.7 Fungi (mycoses)
- 7.7.1 Fungal infections
- 7.7.2 Cryptococcosis
- 7.7.3 Coccidioidomycosis
- 7.7.4 Paracoccidioidomycosis
- 7.7.5 <i>Pneumocystis jirovecii</i>
- 7.7.6 <i>Penicillium marneffei</i> infection
- 7.8 Protozoa
- 7.9 Nematodes (roundworms)
- 7.10 Cestodes (tapeworms)
- 7.11 Trematodes (flukes)
- 7.12 Nonvenomous arthropods
- 7.13 Pentastomiasis (porocephalosis, linguatulosis/linguatuliasis)
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine
Coccidioidomycosis
- Chapter:
- Coccidioidomycosis
- Author(s):
Gregory M. Anstead
and John R. Graybill
- DOI:
- 10.1093/med/9780199204854.003.070703_update_001
Update:
Diagnosis—laboratory precautions and handling rules; new diagnostic tests.
Clinical presentation—community-acquired pneumonia.
Treatment—selection of antifungal agents.
Coccidioidomycosis results from inhalation of arthroconidia of Coccidioides spp., which are soil fungi endemic to the south-western United States of America and parts of Latin America. Most infections are asymptomatic, but primary infection may resemble community-acquired pneumonia, sometimes with hypersensitivity manifestations such as erythema nodosum, erythema multiforme, and arthritis. Acute pulmonary infection usually resolves spontaneously, but—especially in immunocompromised patients, African Americans, and Filipinos—it may progress to persistent pulmonary disease or disseminate to skin, soft tissues, the osteoarticular system, and the central nervous system. Diagnosis is by culture, histopathology or serology. Fluconazole and itraconazole are usually the initial drugs of choice, with amphotericin B reserved for severe pulmonary and disseminated disease, and in pregnancy. In refractory cases, posaconazole and voriconazole are alternative antifungal agents....
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- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 7.1 Pathogenic microorganisms and the host
- 7.2 The patient with suspected infection
- 7.3 Immunization
- 7.4 Travel and expedition medicine
- 7.5 Viruses
- 7.6 Bacteria
- 7.7 Fungi (mycoses)
- 7.7.1 Fungal infections
- 7.7.2 Cryptococcosis
- 7.7.3 Coccidioidomycosis
- 7.7.4 Paracoccidioidomycosis
- 7.7.5 <i>Pneumocystis jirovecii</i>
- 7.7.6 <i>Penicillium marneffei</i> infection
- 7.8 Protozoa
- 7.9 Nematodes (roundworms)
- 7.10 Cestodes (tapeworms)
- 7.11 Trematodes (flukes)
- 7.12 Nonvenomous arthropods
- 7.13 Pentastomiasis (porocephalosis, linguatulosis/linguatuliasis)
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine