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Francisella tularensis infection 

Francisella tularensis infection
Francisella tularensis infection

Petra C.F. Oyston


May 30, 2013: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.



Pathogenesis (including mechanisms for intracellular survival and identification virulence genes).

Laboratory identification.

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date: 27 October 2021

Fransicella tularensis is a small Gram-negative coccobacillus that circulates in small rodents, rabbits and hares, most frequently in Scandinavia, northern North America, Japan, and Russia. Clinical presentation depends on the route of infection. Most commonly this follows the bite of an infected arthropod vector, resulting in ulceroglandular tularaemia. The most acute and life-threatening disease, respiratory or pneumonic tularaemia, arises following inhalation of infectious aerosols or dusts. The organism is highly fastidious, requiring rich media for isolation and specialized reagents for positive identification; most cases are diagnosed serologically. Treatment is with supportive care and antibiotics (usually ciprofloxacin, doxycycline or gentamicin). There is no vaccine....

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