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Intracellular klebsiella infections (donovanosis and rhinoscleroma) 

Intracellular klebsiella infections (donovanosis and rhinoscleroma)
Intracellular klebsiella infections (donovanosis and rhinoscleroma)

J. Richens



Addition of molecular diagnostic tests for donovanosis.

Addition of donovanosis treatment guidelines.

Update on pathogenesis of rhinoscleroma.

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date: 25 October 2021

Two rare intracellular species of Klebsiella, a Gram-negative bacillus, cause granulomatous disease in humans that is found in small endemic foci in warm climates, linked to poverty and poor hygiene.

Donovanosis—caused by Klebsiella granulomatis (until recently named Calymmatobacterium granulomatis); presumed to be sexually transmitted; presents with genital ulcers or growths, often accompanied by an inguinal ‘pseudobubo’ (granuloma inguinale). Diagnosed by demonstrating Donovan bodies (vacuoles containing capsulated coccoid bacteria) lying within histiocytes in material taken from a typical lesion. Treatment is with azithromycin; surgery may be needed for complications....

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