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Neisseria gonorrhoeae 

Neisseria gonorrhoeae
Neisseria gonorrhoeae

D. Barlow

, Jackie Sherrard

, and C. Ison


July 30, 2015: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.


Recommendations for treatment of gonorrhoea no longer include oral cefixime.

All commercially available NAATs (2011) may react with nongonococcal strains although newer diagnostic tests produce fewer false positives.

A test of cure following treatment for gonococcal infection is now recommended.

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date: 27 September 2021

Neisseria gonorrhoeae is a Gram-negative, intracellular diplococcus that primarily colonizes the columnar epithelium of lower genital tract, only occasionally spreading to the upper genital tract or causing systemic disease. It is almost exclusively transmitted by sexual activity.

Clinical features—(1) Oropharyngeal and rectal infections usually produce no symptoms; (2) men—dysuria (50%) and urethral discharge (98%) develop after a median of more than 5 days; complications, e.g. epididymitis, orchitis, are rare; (3) women—there are no specific symptoms in the absence of complications, e.g. salpingitis, bartholinitis; (4) disseminated gonococcal infection—a comparatively benign bacteraemia affecting joints (particularly shoulder and knee) and skin; more common in women than men....

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