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Bala Hota

, Kyle J. Popovich

, and Robert A. Weinstein



Pathogenesis – genome sequencing can identify toxins associated with worse clinical outcomes.

Prevention – discussion of factors associated with recent decline in incidence of hospital-onset S. aureus bacteremias.

Treatment – discussion of (1) early modification of therapy if blood cultures fail to clear rapidly; (2) a new antibiotic, tedizolid; (3) recent study comparing 6 vs 12 weeks of therapy for pyogenic vertebral osteomyelitis.

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date: 27 September 2021

Staphylococci are Gram-positive cocci that form clusters, but can occur singly, in pairs, chains, or tetrads. They are classically distinguished from other Gram-positive cocci by presence of catalase, an enzyme that degrades hydrogen peroxide (H2O2). S. aureus is distinguished from other coagulase-negative staphylococci, which are generally less virulent, by the presence of coagulase, an enzyme that coagulates plasma. Many toxins and regulatory elements enhance virulence in staphylococci....

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