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David A. Warrell



Prevention—live attenuated virus vaccines.

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date: 27 September 2021

Orf (‘ecthyma contagiosum’) is caused by an epitheliotropic parapox DNA virus of sheep and goats that is able to subdue the host’s immune response. It is an occupational zoonosis of people working with these animals. A painful papule/pustule develops, usually on a finger, the site of contact with lesions on the animal’s muzzle. Systemic effects are unusual, but include local lymphadenopathy, fever, erythema multiforme, and other generalized rashes. Spontaneous resolution within 6 weeks is usual. Multiple, giant lesions may develop in the immunosuppressed. Topical cidofovir is effective in severe cases....

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