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Bridget Wills

and Jeremy Farrar


February 27, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.


Epidemiology—expanding geographical range (Pacific Region, Americas, Africa, the Arabian Peninsula, and even the warmer parts of Europe).

Potential drug therapy—failure of chloroquine.

Vaccines—continuing trials of experimental ChimeriVax-Dengue vaccine.

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date: 23 October 2021

Dengue is caused by a flavivirus and is the most important mosquito-borne viral infection of humans. Some 40 million symptomatic infections are estimated to occur annually. The disease is hyper-endemic in many large Asian cities, and is also a significant problem in the Pacific region and in the Americas. The primary mosquito vector is ...

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