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Herpesviruses (excluding Epstein–Barr virus) 

Herpesviruses (excluding Epstein–Barr virus)
Herpesviruses (excluding Epstein–Barr virus)

J.G.P. Sissons



Herpes simplex virus encephalitis—rare mutations of Toll-like Receptor 3 signalling pathway associated with primary HSV encephalitis in children.

Human cytomegalovirus disease (HCMVD)—in the face of ganciclovir resistance other drugs are being tested including artesunate.

HCMV vaccine—a recombinant glycoprotein B based HCMV vaccine in seronegative women reduced incidence of maternal and congenital CMV infection.

Kaposi sarcoma—pathogenesis of angioproliferative and inflammatory Kaposi’s sarcoma lesions, ‘paracrine neoplasia’.

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date: 23 October 2021

Eight human herpesviruses, all with a linear double-stranded DNA genome and divided into alpha-, beta-, and gamma-subfamilies on the basis of genomic and biological properties, share the capacity to produce latent infection. The diseases they cause may result from primary infection, or reactivation of the virus from latency, and tend to be more severe in immunosuppressed patients. Diagnosis of the various herpesvirus infections may be made on clinical grounds alone, by culture or demonstration of viral particles by electron microscopy of relevant samples, by serological testing, or (increasingly) by PCR-based tests....

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