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Human prion diseases 

Human prion diseases
Human prion diseases

R G Will



Number of cases of iatrogenic CJD worldwide updated.

Number of cases of vCJD worldwide updated.

Diagnostic criteria for sporadic CJD updated to include MRI brain scan.

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date: 24 September 2021

Prion protein (for proteinacious infectious particle) is a membrane-associated glycoprotein present in all mammalian species. Its normal function is unknown, but in prion diseases (also known as transmissible spongiform encephalopathies) a post-translationally modified form of the protein, partially resistant to protease digestion, is deposited in the brain and associated—after long incubation periods—with neuronal dysfunction and death....

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