- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 24.1 Introduction and approach to the patient with neurological disease
- 24.2 Mind and brain: building bridges linking neurology, psychiatry, and psychology
- 24.3 Clinical investigation of neurological disease
- 24.4 Higher cerebral function
- 24.5 Epilepsy and disorders of consciousness
- 24.6 Disorders of the special senses
- 24.7 Disorders of movement
- 24.8 Headache
- 24.9 Brainstem syndromes
- 24.10 Specific conditions affecting the central nervous system
- 24.11 Infections of the central nervous system
- 24.11.1 Bacterial infections
- 24.11.2 Viral infections
- 24.11.3 Intracranial abscesses
- 24.11.4 Neurosyphilis and neuro-AIDS
- 24.11.5 Human prion diseases
- 24.12 Disorders of cranial nerves
- 24.13 Disorders of the spinal cord
- 24.14 Diseases of the autonomic nervous system
- 24.15 The motor neuron diseases
- 24.16 Diseases of the peripheral nerves
- 24.17 Inherited neurodegenerative diseases
- 24.18 Developmental abnormalities of the central nervous system
- 24.19 Acquired metabolic disorders and the nervous system
- 24.20 Neurological complications of systemic disease
- 24.21 Paraneoplastic neurological syndromes
- 24.22 Autoimmune limbic encephalitis and Morvan’s syndrome
- 24.23 Disorders of the neuromuscular junction
- 24.24 Disorders of muscle
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine
Neurosyphilis and neuro-AIDS
- Chapter:
- Neurosyphilis and neuro-AIDS
- Author(s):
Hadi Manji
- DOI:
- 10.1093/med/9780199204854.003.0241104
Invasion of the central nervous system occurs early in the course of syphilis infection. Neurosyphilis causes meningitis, myeloradiculopathy due to pachymeningitis, and gummatous cord and brain lesions; endarteritis may cause infarction.
Clinical features—these are protean: neurosyphilis should always be considered in the diagnosis of neurological disorders without a convincing explanation, including (1) stroke—especially in young patients; (2) ocular abnormalities—e.g. optic neuritis, choroidoretinitis, pupillary abnormalities; (3) unexplained cranial nerve disease, including sensorineural deafness and vertigo; (4) dementia—low-grade meningo-encephalitis is associated with generalized changes in the brain and occasionally with frontotemporal dementia; (5) tabes dorsalis—a sensory ataxia caused by disease of the dorsal roots, ganglia and posterior columns....
Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.
Please subscribe or login to access full text content.
If you have purchased a print title that contains an access token, please see the token for information about how to register your code.
For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.
- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 24.1 Introduction and approach to the patient with neurological disease
- 24.2 Mind and brain: building bridges linking neurology, psychiatry, and psychology
- 24.3 Clinical investigation of neurological disease
- 24.4 Higher cerebral function
- 24.5 Epilepsy and disorders of consciousness
- 24.6 Disorders of the special senses
- 24.7 Disorders of movement
- 24.8 Headache
- 24.9 Brainstem syndromes
- 24.10 Specific conditions affecting the central nervous system
- 24.11 Infections of the central nervous system
- 24.11.1 Bacterial infections
- 24.11.2 Viral infections
- 24.11.3 Intracranial abscesses
- 24.11.4 Neurosyphilis and neuro-AIDS
- 24.11.5 Human prion diseases
- 24.12 Disorders of cranial nerves
- 24.13 Disorders of the spinal cord
- 24.14 Diseases of the autonomic nervous system
- 24.15 The motor neuron diseases
- 24.16 Diseases of the peripheral nerves
- 24.17 Inherited neurodegenerative diseases
- 24.18 Developmental abnormalities of the central nervous system
- 24.19 Acquired metabolic disorders and the nervous system
- 24.20 Neurological complications of systemic disease
- 24.21 Paraneoplastic neurological syndromes
- 24.22 Autoimmune limbic encephalitis and Morvan’s syndrome
- 24.23 Disorders of the neuromuscular junction
- 24.24 Disorders of muscle
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine