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Large-scale randomized evidence: trials and meta-analyses of trials 

Large-scale randomized evidence: trials and meta-analyses of trials
Large-scale randomized evidence: trials and meta-analyses of trials

C. Baigent

, R. Peto

, R. Gray

, S. Parish

, and R. Collins



Chapter reviewed June 2011—no substantial updates required.

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date: 19 September 2021

As long as doctors start with a healthy scepticism about the many apparently striking claims and counter-claims that appear in the medical literature, trial results do make sense. The main enemy of common sense is over-optimism: there are a few striking exceptions where treatments for serious disease work extremely well, but many claims of vast improvements from new therapies turn out to be evanescent....

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