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Anaphylaxis 

Anaphylaxis
Chapter:
Anaphylaxis
DOI:
10.1093/med/9780199202447.003.0018
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date: 14 October 2019

Anaphylaxis 110

Anaphylactic reactions (type I hypersensitivity reaction) are the consequence of the cascade caused by an IgE-mediated response to a specific antigen. Prior exposure to the antigen sensitizes the individual, so that subsequent exposure results in prostaglandin, leukotriene, and platelet activating factor generation and thereby histamine release. This results in vasodilatation, bronchial mucosal oedema, and bronchoconstriction....

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