Show Summary Details
Page of

Clinical 

Clinical
Author(s):

Paul Farquhar-Smith

, Pierre Beaulieu

, and Sian Jagger

Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 04 December 2020

The landmark paper discussed in this chapter is ‘Epidural morphine in treatment of pain’, published by Behar et al. in 1979. A small case series in the seventies first highlighted the use of epidural morphine for pain. It consists of only ten patients who were all administered 2 mg of morphine epidurally. Patients suffering from both acute and chronic pain had a significant reduction in the level of pain within 2–3 minutes, and this lasted 6–24 hours. The authors went on to postulate that morphine produced its effect by a direct action on the specific opioid receptors in the substantia gelatinosa. Although morphine is rarely used epidurally, this paper paved the way for the use of epidural opioids in many different pain conditions.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.