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Pregabalin in the reduction of chronic pain post knee surgery 

Pregabalin in the reduction of chronic pain post knee surgery
Chapter:
Pregabalin in the reduction of chronic pain post knee surgery
Author(s):

Richard M. Langford

DOI:
10.1093/med/9780198834359.003.0074
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date: 16 January 2021

The paper discussed in this chapter, published in 2010 by Buvanendran et al. is entitled ‘Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial.’ Chronic (or persistent) post-surgical pain is defined as pain that develops after surgical intervention and lasts at least 2 months; other causes being excluded, in particular pain from a condition preceding surgery. The subject of the commentary reviewed in this chapter is a study conducted in 2006–7, regarded as a pivotal step to establish the role of gabapentinoids, and in particular pregabalin, for both perioperative pain management and prevention of chronic post-surgical neuropathic pain, specifically persisting neuropathic pain after total knee arthroplasty.

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