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Pregabalin in the reduction of chronic pain post knee surgery 

Pregabalin in the reduction of chronic pain post knee surgery
Pregabalin in the reduction of chronic pain post knee surgery

Richard M. Langford

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date: 27 October 2021

The paper discussed in this chapter, published in 2010 by Buvanendran et al. is entitled ‘Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial.’ Chronic (or persistent) post-surgical pain is defined as pain that develops after surgical intervention and lasts at least 2 months; other causes being excluded, in particular pain from a condition preceding surgery. The subject of the commentary reviewed in this chapter is a study conducted in 2006–7, regarded as a pivotal step to establish the role of gabapentinoids, and in particular pregabalin, for both perioperative pain management and prevention of chronic post-surgical neuropathic pain, specifically persisting neuropathic pain after total knee arthroplasty.

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