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DNIC and prediction of chronic post-surgical pain 

DNIC and prediction of chronic post-surgical pain
DNIC and prediction of chronic post-surgical pain

Sibtain Anwar

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date: 24 September 2021

The landmark paper discussed in this chapter is ‘Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk’, published by Yarnitsky et al. in 2008. These authors were the first to report that it was possible to predict persistent post-surgical pain (PPP) before surgery took place, through the use of a laboratory-based assessment of endogenous analgesia: diffuse noxious inhibitory controls (DNIC). Similar peripheral tissue damage at the time of surgery leads to a wide range of PPP intensities and trajectories in different patients. This is likely to be related to individual variations in central pain processing and modulation. A key mechanism in this central modulation is the endogenous analgesic system, which can be assessed via the use of the DNIC platform.

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