- Section 1 Historical
- Section 2 Firsts
- Chapter 21 The key role of nerve growth factor in inflammatory pain processing
- Chapter 22 Mapping of neurotrophin receptors on adult sensory neurons
- Chapter 23 Plasticity in somatic receptive fields after nerve injury
- Chapter 24 Peripheral neural mechanisms of cutaneous heat hyperalgesia and heat pain
- Chapter 25 The cloning and characterization of the cannabinoid type 1 receptor
- Chapter 26 Deorphanization of ORL-1/LC132 by reverse pharmacology in two landmark studies
- Chapter 27 The capsaicin receptor
- Chapter 28 VR1 in inflammatory thermal hyperalgesia
- Chapter 29 A signature of pain in the brain
- Chapter 30 Cytokines as central to peripheral sensitization and hyperalgesia
- Chapter 31 Endogenous opioids mediate stress-induced analgesia
- Chapter 32 The first crystal structure of an ionotropic glutamate receptor ligand-binding core
- Chapter 33 Control of pain initiation by endogenous cannabinoids
- Chapter 34 Peripheral analgesia involves cannabinoid receptors
- Chapter 35 Glia
- Chapter 36 The challenges of animal models of pain
- Chapter 37 Mechanisms of bone cancer pain
- Chapter 38 The molecular structure of the <span xml:lang="ell">μ</span>-opioid receptor
- Chapter 39 The milestone effect of DNIC in our understanding of pain
- Chapter 40 The original description of central sensitization
- Chapter 41 The molecular basis for the placebo effect
- Section 3 Science
- Section 4 Clinical
- Section 5 Mechanisms
- Section 6 Neuropathic
- Section 7 Psychosocial
- Section 8 Genetics
(p. 130) The challenges of animal models of pain
- Chapter:
- (p. 130) The challenges of animal models of pain
- Author(s):
Muhammad Saad Yousuf
, and Bradley J. Kerr
- DOI:
- 10.1093/med/9780198834359.003.0036
The landmark paper discussed in this chapter is ‘Animal models of pain: progress and challenges’, published in the journal Nature Reviews Neuroscience by Jeff Mogil of McGill University in 2009. The most common symptom across various medical conditions and a major reason for seeking physician consultation is pain. It is defined as ‘an unpleasant feeling or emotional experience associated with actual or potential tissue damage’. A large percentage of the research investigating the biological mechanisms of pain is performed on animals. Human studies of pain are limited by lack of practicality, subjectivity, and ethical considerations. This influential review by Mogil discusses the progress and challenges faced in studying pain using various animal models.
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- Section 1 Historical
- Section 2 Firsts
- Chapter 21 The key role of nerve growth factor in inflammatory pain processing
- Chapter 22 Mapping of neurotrophin receptors on adult sensory neurons
- Chapter 23 Plasticity in somatic receptive fields after nerve injury
- Chapter 24 Peripheral neural mechanisms of cutaneous heat hyperalgesia and heat pain
- Chapter 25 The cloning and characterization of the cannabinoid type 1 receptor
- Chapter 26 Deorphanization of ORL-1/LC132 by reverse pharmacology in two landmark studies
- Chapter 27 The capsaicin receptor
- Chapter 28 VR1 in inflammatory thermal hyperalgesia
- Chapter 29 A signature of pain in the brain
- Chapter 30 Cytokines as central to peripheral sensitization and hyperalgesia
- Chapter 31 Endogenous opioids mediate stress-induced analgesia
- Chapter 32 The first crystal structure of an ionotropic glutamate receptor ligand-binding core
- Chapter 33 Control of pain initiation by endogenous cannabinoids
- Chapter 34 Peripheral analgesia involves cannabinoid receptors
- Chapter 35 Glia
- Chapter 36 The challenges of animal models of pain
- Chapter 37 Mechanisms of bone cancer pain
- Chapter 38 The molecular structure of the <span xml:lang="ell">μ</span>-opioid receptor
- Chapter 39 The milestone effect of DNIC in our understanding of pain
- Chapter 40 The original description of central sensitization
- Chapter 41 The molecular basis for the placebo effect
- Section 3 Science
- Section 4 Clinical
- Section 5 Mechanisms
- Section 6 Neuropathic
- Section 7 Psychosocial
- Section 8 Genetics