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The cloning and characterization of the cannabinoid type 1 receptor 

The cloning and characterization of the cannabinoid type 1 receptor
The cloning and characterization of the cannabinoid type 1 receptor

Mary E. Abood

, and Thomas Gamage

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date: 16 October 2021

The cloning and characterization of the first cannabinoid receptor (now known as the cannabinoid type 1 (CB1) receptor) by Matsuda et al. in the landmark paper discussed in this chapter was a seminal discovery in 1990. While the analgesic properties of marijuana had been known for thousands of years, the mechanisms through which marijuana produces analgesia were not understood. The identification and functional characterization of the CB1 receptor led to the discovery of an endogenous cannabinoid system (the endocannabinoid system), which has now been shown to be important not only for acute and chronic pain states, but also for a whole host of physiological and pathophysiological disorders.

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