- Section 1 Historical
- Section 2 Firsts
- Chapter 21 The key role of nerve growth factor in inflammatory pain processing
- Chapter 22 Mapping of neurotrophin receptors on adult sensory neurons
- Chapter 23 Plasticity in somatic receptive fields after nerve injury
- Chapter 24 Peripheral neural mechanisms of cutaneous heat hyperalgesia and heat pain
- Chapter 25 The cloning and characterization of the cannabinoid type 1 receptor
- Chapter 26 Deorphanization of ORL-1/LC132 by reverse pharmacology in two landmark studies
- Chapter 27 The capsaicin receptor
- Chapter 28 VR1 in inflammatory thermal hyperalgesia
- Chapter 29 A signature of pain in the brain
- Chapter 30 Cytokines as central to peripheral sensitization and hyperalgesia
- Chapter 31 Endogenous opioids mediate stress-induced analgesia
- Chapter 32 The first crystal structure of an ionotropic glutamate receptor ligand-binding core
- Chapter 33 Control of pain initiation by endogenous cannabinoids
- Chapter 34 Peripheral analgesia involves cannabinoid receptors
- Chapter 35 Glia
- Chapter 36 The challenges of animal models of pain
- Chapter 37 Mechanisms of bone cancer pain
- Chapter 38 The molecular structure of the <span xml:lang="ell">μ</span>-opioid receptor
- Chapter 39 The milestone effect of DNIC in our understanding of pain
- Chapter 40 The original description of central sensitization
- Chapter 41 The molecular basis for the placebo effect
- Section 3 Science
- Section 4 Clinical
- Section 5 Mechanisms
- Section 6 Neuropathic
- Section 7 Psychosocial
- Section 8 Genetics
(p. 82) Mapping of neurotrophin receptors on adult sensory neurons
- Chapter:
- (p. 82) Mapping of neurotrophin receptors on adult sensory neurons
- Author(s):
Elizabeth J. Bradbury
, and Nicholas D. James
- DOI:
- 10.1093/med/9780198834359.003.0022
The paper discussed in this chapter describes the first mapping of neurotrophin receptors in adult sensory neurons. Neurotrophins and their receptors were a particularly hot topic at the time, but the primary focus of interest had been in their role in development. In this paper, McMahon and colleagues characterized both mRNA and protein expression of the recently discovered trk receptors on defined populations of adult sensory neurons, correlating trk expression with other primary afferent projection neuron properties such as cell size and neuronal function. Furthermore, by showing clear correlations between the expression of different trk receptors and the physical and functional properties of defined primary afferent projections, the authors provided key evidence suggesting that nerve growth factor and neurotrophin-3 acted on functionally distinct populations of adult sensory neurons. This paper provided the basis for subsequent research on neurotrophin signalling and function in both the healthy and the diseased nervous system.
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- Section 1 Historical
- Section 2 Firsts
- Chapter 21 The key role of nerve growth factor in inflammatory pain processing
- Chapter 22 Mapping of neurotrophin receptors on adult sensory neurons
- Chapter 23 Plasticity in somatic receptive fields after nerve injury
- Chapter 24 Peripheral neural mechanisms of cutaneous heat hyperalgesia and heat pain
- Chapter 25 The cloning and characterization of the cannabinoid type 1 receptor
- Chapter 26 Deorphanization of ORL-1/LC132 by reverse pharmacology in two landmark studies
- Chapter 27 The capsaicin receptor
- Chapter 28 VR1 in inflammatory thermal hyperalgesia
- Chapter 29 A signature of pain in the brain
- Chapter 30 Cytokines as central to peripheral sensitization and hyperalgesia
- Chapter 31 Endogenous opioids mediate stress-induced analgesia
- Chapter 32 The first crystal structure of an ionotropic glutamate receptor ligand-binding core
- Chapter 33 Control of pain initiation by endogenous cannabinoids
- Chapter 34 Peripheral analgesia involves cannabinoid receptors
- Chapter 35 Glia
- Chapter 36 The challenges of animal models of pain
- Chapter 37 Mechanisms of bone cancer pain
- Chapter 38 The molecular structure of the <span xml:lang="ell">μ</span>-opioid receptor
- Chapter 39 The milestone effect of DNIC in our understanding of pain
- Chapter 40 The original description of central sensitization
- Chapter 41 The molecular basis for the placebo effect
- Section 3 Science
- Section 4 Clinical
- Section 5 Mechanisms
- Section 6 Neuropathic
- Section 7 Psychosocial
- Section 8 Genetics