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Genetic differences in opiate receptors 

Genetic differences in opiate receptors
Genetic differences in opiate receptors

Jeffrey S. Mogil

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date: 19 September 2021

The 1975 manuscript ‘Opioid receptors in mice: Genetic differences’ by Baran and colleagues was the first published paper to forward a hypothesis as to what might underlie mouse strain differences in opioid analgesic response. A strain was identified, CXBK, that exhibited both deficient morphine analgesia and low μ‎-opioid receptor density. Further study of this strain over the next two decades proved very useful, and the phenotype of CXBK mice has now been explained at the molecular level. The Baran et al. paper presaged the modern genetic studies of the μ‎-opioid gene, OPRM1, and was an important early example of the very active modern field of pain genetics.

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