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Drug pharmacokinetics and abuse liability 

Drug pharmacokinetics and abuse liability
Chapter:
Drug pharmacokinetics and abuse liability
Author(s):

David J. Nutt

and Liam J. Nestor

DOI:
10.1093/med/9780198797746.003.0005
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date: 24 June 2019

Pharmacokinetics refers to the effect of the body on drugs. Pharmacokinetics is divided into several areas including the extent and rate of absorption, distribution, metabolism, and excretion of substances. The rapid delivery of drugs like cocaine and nicotine, for example, enhances their effects in reward brain circuitry, and the rate at which the body can metabolize a substance may also make it more reinforcing. Pharmacokinetics, therefore, plays an important role in substance abuse and addiction and its treatment.

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