Show Summary Details
Page of

Neurobiological processes in addiction 

Neurobiological processes in addiction
Chapter:
Neurobiological processes in addiction
Author(s):

David J. Nutt

and Liam J. Nestor

DOI:
10.1093/med/9780198797746.003.0004
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 12 November 2019

The brain is involved in controlling necessary motivational and cognitive processes optimized for survival. These processes can be disrupted by substances of addiction. The key neural substrates underlying these processes are made up of a network of four independent and overlapping brain circuits. These circuits govern reward processing, motivation and/or drive, learning and memory, and cognitive control. Anomalies within these circuits may also pre-date the addiction state, and facilitate the progress from experimentation to substance addiction. The subsequent excessive and chronic use of substances further exacerbates these abnormalities. Therefore, these brain circuits and key psychological processes related to their functioning must be understood if we are to develop and test new pharmacological and psychological treatment approaches in substance addiction.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.