Show Summary Details
Page of

Traumatic brain injury 

Traumatic brain injury
Traumatic brain injury

Lisa A. DelSignore

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 27 July 2021

Chapter 7 covers the definition, epidemiology, pathophysiology, and management of traumatic brain injury (TBI). It explains the fundamental concepts of brain physiology: intracranial compliance; intracranial hypertension; cerebral perfusion pressure; cerebral blood flow; and autoregulation. Medical management of TBI is detailed, including hyperosmolar therapy and nutritional support. Neuromonitoring of patients with TBI in the intensive care unit is discussed, including the evidence base for seizure monitoring and antiepileptic drug prophylaxis. Patients with severe TBI and refractory intracranial hypertension may need escalation to second-tier therapies, which are evaluated, including the evidence for decompressive craniectomy. A concise summary of the different therapies is included.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.