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Andrea E. Cavanna

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date: 04 December 2020

Lamotrigine is a second-generation antiepileptic drug characterized by a wide range of antiepileptic indications, with an acceptable interaction profile in polytherapy. It has a good behavioural tolerability profile and a wide range of psychiatric uses. In patients with epilepsy, lamotrigine has shown antidepressant properties, as well as mixed effects on anxiety symptoms. Adverse behavioural effects (irritability, agitation, and aggression) are not very common and are usually observed in patients with learning disability. Lamotrigine has a licensed indication for the prevention of depressive episodes associated with bipolar disorder (a widespread use of this antiepileptic drug), whereas it is not indicated for manic phases.

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