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Andrea E. Cavanna

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date: 11 July 2020

Ethosuximide is a first-generation antiepileptic drug characterized by few antiepileptic indications, with acceptable interaction profile in polytherapy. Ethosuximide has a good behavioural tolerability profile, but no approved indications or clinical uses in psychiatry. Behavioural adverse effects can sometimes occur following cessation of seizures and normalization of the EEG and resolve with discontinuation of Ethosuximide and seizure recurrence. Specifically, there are reports of psychosis (but no aggression-related behaviours) in adult patients treated with Ethosuximide. Since the psychotic symptoms tend to occur in clear time relation to the Ethosuximide treatment, it seems plausible that they are manifestations of alternative psychosis in the context of forced normalization.

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