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Clonazepam and clobazam 

Clonazepam and clobazam
Clonazepam and clobazam

Andrea E. Cavanna

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date: 11 July 2020

Clonazepam and clobazam are first-generation antiepileptic drugs characterized by few antiepileptic indications, with good interaction profile in polytherapy. Both clonazepam and clobazam are benzodiazepines with an acceptable behavioural tolerability profile and a good range of psychiatric uses (especially anxiety disorders, alcohol withdrawal, insomnia). Clobazam has an indication for short-term relief (2–4 weeks) of acute anxiety in patients who have not responded to other drugs, with or without insomnia, and without uncontrolled clinical depression. As with all benzodiazepines, caution should be used in consideration of the potential for tolerance and addiction, as well as the risks related to respiratory depression.

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