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Carbamazepine, oxcarbazepine, and eslicarbazepine 

Carbamazepine, oxcarbazepine, and eslicarbazepine
Chapter:
Carbamazepine, oxcarbazepine, and eslicarbazepine
Author(s):

Andrea E. Cavanna

DOI:
10.1093/med/9780198791577.003.0003
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date: 10 July 2020

Carbamazepine is a first-generation antiepileptic drug characterized by a good range of antiepileptic indications, with acceptable risk of interactions in polytherapy. Carbamazepine has a very good behavioural tolerability profile and is in widespread psychiatric use (indication for bipolar disorder—acute mania). Oxcarbazepine and eslicarbazepine are carbamazepine derivatives. Oxcarbazepine is a second-generation antiepileptic drug characterized by a good range of antiepileptic indications, with acceptable risk of interactions in polytherapy. Like carbamazepine, oxcarbazepine has a very good behavioural tolerability profile and potential for widespread psychiatric use. Eslicarbazepine is a third-generation antiepileptic drug for which clinical experience is still limited. Little is known about its positive and negative psychotropic properties and their implications for the management of behavioural symptoms in patients with epilepsy.

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