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Antiepileptic drugs and behaviour: mechanisms of action 

Antiepileptic drugs and behaviour: mechanisms of action
Chapter:
Antiepileptic drugs and behaviour: mechanisms of action
Author(s):

Andrea E. Cavanna

DOI:
10.1093/med/9780198791577.003.0002
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date: 23 October 2019

Antiepileptic drugs (AEDs) exert their pharmacological properties on both epileptic seizures and behaviour through different mechanisms of action. These include modulation of ion (mainly sodium and calcium) conductance through voltage-gated channels located within the neuronal membrane, as well as facilitation of inhibitory (GABAergic) neurotransmission and inhibition of excitatory (glutamatergic) neurotransmission, resulting in regulation of neuronal excitability.

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