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Valproate 

Valproate
Chapter:
Valproate
Author(s):

Andrea E. Cavanna

DOI:
10.1093/med/9780198791577.003.0014
Page of

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date: 17 August 2019

Valproate is a first-generation antiepileptic drug characterized by a wide range of antiepileptic indications, with an acceptable interaction profile in polytherapy. Valproate has a good behavioural tolerability profile, despite the existence of occasional reports of depression, irritability, and other behavioural symptoms in patients with encephalopathy. Valproate is also characterized by a wide range of psychiatric uses. Most importantly, valproate is an effective mood stabilizser, with a licensed indication for the treatment of acute mania in patients with bipolar affective disorder. Although it has no formal indication, it is also considered as a first-line agent for maintenance treatment in bipolar affective disorder.

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