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Andrea E. Cavanna

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date: 13 July 2020

Topiramate is a second-generation antiepileptic drug characterized by a good range of antiepileptic indications, with an acceptable interaction profile in polytherapy. Topiramate has an acceptable behavioural tolerability profile, although it has been associated with a number of negative behavioural effects in patients with epilepsy (in particular depression, irritability, and psychotic symptoms). Identified risk factors for the development of behavioural adverse effects include high starting doses and rapid titration schedules, as well as personal or family history of psychiatric disorders. Topiramate has a restricted range of psychiatric uses , although its clinically significant effect in promoting weight loss in patients with behavioural problems can increase its potential usefulness in psychiatric populations.

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