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Andrea E. Cavanna

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date: 03 July 2020

Tiagabine is a second-generation antiepileptic drug characterized by few antiepileptic indications, with an acceptable interaction profile in polytherapy. Tiagabine has an acceptable behavioural tolerability profile, although its use in the treatment of epileptic seizures has declined. Moreover, treatment with tiagabine has often been associated with depression and irritability (especially in patients with a personal history of affective disorders, or in case of rapid initial titration). Tiagabine has no approved indications or clinical uses in psychiatry. Although tiagabine has been occasionally prescribed off-label as adjunctive treatment for anxiety disorders and neuropathic pain, there is no conclusive evidence for its efficacy in the treatment of any behavioural problems.

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