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Behavioural co-morbidities in epilepsy 

Behavioural co-morbidities in epilepsy
Behavioural co-morbidities in epilepsy

Andrea E. Cavanna

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date: 15 July 2020

The association between epilepsy and specific behavioural co-morbidities has long been recognized. The most common and clinically significant psychiatric disorders reported by patients with epilepsy encompass affective, anxiety, and psychotic symptoms. Behavioural co-morbidities in epilepsy can be classified according to the temporal relationship with seizures—inter-ictal, peri-ictal (pre-ictal, ictal, post-ictal), and para-ictal symptomatology. Antiepileptic drugs (AEDs) can modulate behavioural changes in patients with epilepsy through different pathways and are directly responsible for the clinical phenomenon of ‘forced normalization’ (‘alternative psychosis’).

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