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Medical conditions associated with immunocompromise 

Medical conditions associated with immunocompromise
Medical conditions associated with immunocompromise

Simon M. Fox

, Angela M. Minassian

, Thomas Rawlinson

, and Brian J. Angus

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date: 10 July 2020

In addition to conditions more usually associated with immunodeficiency (e.g. HIV and stem cell or solid organ transplant), several common conditions are known to be associated with defective immune function. This may be the result of pathological processes causing mainly structural damage (e.g. chronic obstructive pulmonary disease and other chronic chest diseases), multisystem disease (e.g. diabetes), or chronic organ failure (e.g. renal and hepatic failure). The degree of immune paresis tends to mirror the progression of the underlying disease. In general, the precise mechanisms of immune dysfunction in many of these conditions are unclear, but the result is usually a broad impairment in immune function.

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