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Infections in haematopoietic stem cell transplant recipients 

Infections in haematopoietic stem cell transplant recipients
Chapter:
Infections in haematopoietic stem cell transplant recipients
Author(s):

Simon M. Fox

, Angela M. Minassian

, Thomas Rawlinson

, and Brian J. Angus

DOI:
10.1093/med/9780198789987.003.0008
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date: 21 October 2019

Haematopoietic stem cell transplantation (HSCT) has a central role in the treatment of a variety of benign and malignant diseases. The major causes of early morbidity and mortality are disease relapse, acute graft-versus-host disease (GvHD), regimen-related toxicity, graft failure, and infection. Long-term survivors of HSCT are at risk of a variety of long-term adverse effects, including chronic GvHD, endocrine disturbances, disease relapse, second malignancy, and, again, infection. The incidence of and types of infection that can develop vary with time since transplantation, different sources of stem cells, different preparative regimens, different types of immunosuppression, comorbidities, and whether the individual experiences chronic GvHD.

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