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Infections in solid organ transplant recipients 

Infections in solid organ transplant recipients
Chapter:
Infections in solid organ transplant recipients
Author(s):

Simon M. Fox

, Angela M. Minassian

, Thomas Rawlinson

, and Brian J. Angus

DOI:
10.1093/med/9780198789987.003.0007
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date: 20 August 2019

Despite advances in prevention and treatment, infection is the most frequent cause of death in the first year post solid organ transplant (SOT). In liver transplant recipients, it is the leading cause of death over the first 1–3 years, with the majority of deaths occurring in the first 3–6 months. Infection is also the main cause of death in kidney transplantation in the immediate post-transplant period. Infection established prior to transplant is difficult to treat in the post-transplant recipient and significant antimicrobial toxicities are common, often due to compromised renal or hepatic function and drug interactions. It is therefore crucial to detect and eliminate any potential pathogens whenever possible prior to transplantation or to design effective prophylactic strategies to prevent the re-emergence of latent infections after transplantation.

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