Show Summary Details
Page of

Viruses 

Viruses
Chapter:
Viruses
Author(s):

Simon M. Fox

, Angela M. Minassian

, Thomas Rawlinson

, and Brian J. Angus

DOI:
10.1093/med/9780198789987.003.0011
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 22 July 2019

Viral infections are particularly important in the immunocompromised and are a leading cause of death in solid organ transplantation and haematopoietic stem cell transplantation. They represent a particular challenge to the clinician as they can present non-specifically, disease can progress rapidly, and treatment options have variable efficacy. Two further important features of viral infection contribute to their significance. The first is the ability of some viruses (particularly the human herpesviruses) to establish latency and reactivate in circumstances of reduced immune suppression. This makes viruses such as Cytomegalovirus, Epstein–Barr virus, herpes simplex virus, and varicella zoster virus key pathogens in the immunocompromised. The second feature is the association between certain viruses and the development of malignancy (e.g. Epstein–Barr virus and human papilloma viruses). The oncogenic potential of these infections and the failure of immune surveillance is exacerbated in the immunocompromised.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.