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Simon M. Fox

, Angela M. Minassian

, Thomas Rawlinson

, and Brian J. Angus

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date: 13 July 2020

The term ‘immunocompromised host’ defines individuals with either non-specific (e.g. skin and mucous membrane, phagocytic activity, and complement) or specific (humoral or cellular immunity) dysfunction of defence mechanisms, or a combination of these. The alteration of these defence mechanisms may be a consequence of underlying disease (e.g. tumours and HIV infection), the effects of medical therapies (e.g. chemotherapy, steroids, immunosuppressants, and radiation), or primary genetic defects. This chapter provides an introduction to the immunocompromised host.

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