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Targeting the circadian system 

Targeting the circadian system
Targeting the circadian system

Gregory D. M. Potter

and Eleanor M. Scott

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date: 20 January 2021

Circadian (approximately 24-hour) rhythms are generated by a hierarchical system responsible for coordinating behaviour and physiology throughout the 24-hour day. Increasing evidence supports roles for disruption of the circadian system in the development of type 2 diabetes (T2DM) and depression. We outline the key aspects of circadian system regulation, discuss the findings indicating that biological disruption of the circadian system produces various behavioural and metabolic abnormalities, and review human studies which show that environmental disruption of the circadian system contributes to T2DM and depression. Finally, we will summarize the therapeutic potential of restoring circadian system organization to manage these diseases.

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