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Treatment of depression in type 2 diabetes 

Treatment of depression in type 2 diabetes
Treatment of depression in type 2 diabetes

Frank Petrak

and Bonnie Röhrig

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date: 19 January 2021

This chapter provides a brief overview of the current scientific evidence for the treatment of depression in type 2 diabetes. Considering the multiple adverse interactions between both conditions, treatment targets should always focus on diabetes-related medical outcome and improvement or remission of depression at the same time in people with diabetes. Depression can be treated with moderate to good results in depressed patients with type 2 diabetes by a variety of psychological and pharmacological interventions, with comparable results to the treatment of depressive patients without diabetes. Results regarding glycaemic control are inconsistent and indicate a low effectiveness of psychological interventions. Antidepressants demonstrated mild to moderate effect regarding better glycaemic control, but the results are still inconclusive and long-term effects are widely unknown. The chapter ends with a critical summary of methodological limitations of the research in that area and concludes with evidence-based recommendations for clinical practice.

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