Neuroprogression in Psychiatry

Neuroprogression in Psychiatry

Edited by Flávio Kapczinski, Michael Berk, and Pedro Vieira da Silva Magalhães

Abstract

Psychiatric disorders are characterized by an overlapping set of pathophysiological pathways that include monoamines but also neurotrophins, apoptotic and mitochondrial pathways, epigenetics, and dysregulation of immunity and redox balance, counterbalanced by cellular resilience and defence pathways and the effects of treatment. These conspire in a subset of individuals to cause changes in brain function and, over time, the activity of these pathways in chronic psychiatric disorders can lead to cognitive sequelae and changes in brain structure. This can lead to differences between early and late stages of illness. These biological underpinnings could explain why late-stage patients are more prone to treatment refractoriness, progressive brain changes, and consequent cognitive and functioning impairment. This process is understood under the construct of neuroprogression, which refers to the pathological rewiring of the brain underlying the clinical and cognitive changes that underpin the staged progression of the illness, caused by activities of the aforementioned biological pathways. It is important to note that the brain can adapt to the challenges of the environment and respond to medications to ameliorate this process. Understanding the process of neuroprogression provides a window into the core biology of the disorder and opens the door to therapeutic approaches addressing these pathways. This book is an account of the state of the art in the field of neuroprogression in different psychiatric disorders.

Bibliographic Information

Publisher:: Oxford University Press

Print Publication Date:: Feb 2019

Print ISBN-13:: 9780198787143

Published online:: Mar 2019

DOI:: 10.1093/med/9780198787143.001.0001

Authors

Flávio Kapczinski, editor Department of Psychiatry and Behavioural Neurosciences, Director, Graduate Program in Neuroscience, McMaster University, Hamilton, ON, Canada

Michael Berk, editor Alfred Deakin Chair of Psychiatry, School of Medicine, Deakin University, Geelong, VIC, Australia; NHMRC Senior Principal Research Fellow, Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia; Honorary Professorial Research Fellow, Florey Institute for Neuroscience and Mental Health and Orygen Youth Health, University of Melbourne, Parkville, VIC, Australia

Pedro Vieira da Silva Magalhães, editor Adjunct Professor, Department of Psychiatry and Legal Medicine, Professor, Postgraduate Program in Psychiatry and Behavioral Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

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Front Matter
- Abbreviations
- Contributors
Chapter 1 A short introductory note about neuroprogression in psychiatryLuis Guilherme Streb, Michael Berk, and Flávio Kapczinski
Chapter 2 Allostasis and neuroprogression in major psychiatric disordersIria Grande, Flávio Kapczinski, Sebastián Camino, Gustavo Vázquez, and Eduard Vieta
Chapter 3 Neuroprogression and accelerated ageing in severe psychiatric disordersElisa Brietzke, Ana S. Yamagata, Pawan K. Maurya, and Lucas B. Rizzo
Chapter 4 Mitochondrial function and inflammation pathways in the neuroprogression of mental disordersAna C. Andreazza, Rajas P. Kale, Angela Duong, Fabio Molina, and Susannah J. Tye
Chapter 5 The role of immuno-inflammatory abnormalities in neuroprogressionElisa Brietzke, Ana S. Yamagata, Raphael Cerqueira, Lucas B. Rizzo, Roger S. McIntyre, and Rodrigo B. Mansur
Chapter 6 Depression and neuroprogression: Sirtuins and mitochondria as crucial hubsGeorge Anderson and Michael Maes
Chapter 7 Neuroprogression in post-traumatic stress disorderRyan M. Cassidy, Ives Cavalcante Passos, and Márcia Kauer-Sant’Anna
Chapter 8 Neuroprogression in anxiety disordersGiampaolo Perna, Elisa Mingotto, Alessandra Alciati, and Daniela Caldirola
Chapter 9 Functioning and illness progression in severe mental illnessAdriane R. Rosa and Flávia Lima
Chapter 10 Neuropsychological functioning and neuroimaging in bipolar disorder: Evidence of neuroprogressionEmre Bora
Chapter 11 Neuroprogression in children and adolescents with bipolar disorderFrancisco Romo-Nava, Jenni E. Farrow, Luis Rodrigo Patino, Fabiano G. Nery, Caleb M. Adler, and Melissa P. DelBello
Chapter 12 Substance abuse and neuroprogressionAnne Orgler Sordi, Silvia Bassani Schuch-Goi, and Lisia von Diemen
Chapter 13 Lifestyle and neuroprogression: Diet, sleep, and exerciseAdrian L. Lopresti and Peter D. Drummond
Chapter 14 The pernicious procession of somatoprogressionJonathan M. Gregory, Benjamin I. Goldstein, and Roger S. McIntyre
End Matter
- Index

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Neuroprogression in Psychiatry

Edited by Flávio Kapczinski, Michael Berk, and Pedro Vieira da Silva Magalhães

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Neuroprogression in Psychiatry

Edited by Flávio Kapczinski, Michael Berk, and Pedro Vieira da Silva Magalhães

Abstract

Bibliographic Information

Authors

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Contents