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Degenerative cardiovascular disease in the elderly 

Degenerative cardiovascular disease in the elderly
Degenerative cardiovascular disease in the elderly

Edgar Argulian



Seniletransthyretin cardiac amyloidosis appears to be an under-recognized but important clinical entity.

Senile cardiac amyloidosis is present in a substantial number of patients with aortic stenosis, especially low-gradient aortic stenosis.

Timely recognition of senile cardiac amyloidosis is critical due to availability of effective treatment.

New references have been added.

Updated on 23 April 2020. The previous version of this content can be found here.
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date: 17 June 2021

The ageing population represents a unique challenge for cardiovascular care. Ageing causes remodelling of the cardiovascular system and commonly results in distinct degenerative changes. Most of these degenerative changes have significant interactions with cardiovascular risk factors by either being a marker of disease burden or being exaggerated by co-morbid conditions. Also, age-related degenerative conditions have physiological and prognostic implications. This chapter discusses several common degenerative cardiovascular conditions in the elderly such as cardiac fibrosis, amyloidosis, mitral annular calcification, and aortic valve sclerosis. Some of these conditions (such as cardiac fibrosis and amyloidosis) are implicated in pathogenesis of heart failure with preserved ejection fraction. Others (such as mitral annular calcification and aortic valve sclerosis) do not typically cause any measurable physiological abnormality but have prognostic significance.

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