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C3 glomerulopathies and ‘idiopathic’ immune complex membranoproliferative glomerulonephritis (MPGN) 

C3 glomerulopathies and ‘idiopathic’ immune complex membranoproliferative glomerulonephritis (MPGN)
C3 glomerulopathies and ‘idiopathic’ immune complex membranoproliferative glomerulonephritis (MPGN)

Richard J Glassock

and Fernando C Fervenza

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date: 02 August 2021

Membranoproliferative glomerulonephritis (MPGN) is also known as mesangiocapillary glomerulonephritis. The term MPGN is a designation given to a ‘pattern of injury’ observed in light microscopy that is consequent to an extremely heterogeneous collection of disorders that manifests as both mesangial hypercellularity and proliferation accompanied by broadening of the peripheral capillary loops, due to reduplication of the glomerular capillary basement membrane (known as ‘double-contour’). As such, MPGN is not a disease diagnosis per se, but a descriptive term covering a patterned (stereotypic) response seen on light microscopy arising from a variety of injurious pathogenetic processes affecting the glomerular capillaries. This chapter discusses the primary C3 glomerulopathies (C3 glomerulonephritis and dense deposit disease, DDD) and the ‘idiopathic’ immune complex forms of MPGN, as together they constitute a distinct category of primary glomerulonephritis.

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