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Immunoglobulin A nephropathy 

Immunoglobulin A nephropathy
Chapter:
Immunoglobulin A nephropathy
Author(s):

Richard J Glassock

, Claudio Ponticelli

, and Kar Neng Lai

DOI:
10.1093/med/9780198784081.003.0007
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date: 19 October 2020

Immunoglobulin A nephropathy (IgA nephropathy or IgA N) refers to a primary glomerular disease characterized by the dominant or co-dominant, diffuse, and generalized mesangial deposition of IgA, typically of the IgA1 subclass, often accompanied by deposition of IgG and the C3 and or C4, but not C1q, components of complement in a similar distribution. IgA N is most likely the commonest primary glomerular disease in the developed world, and the disease is characterized principally by episodes of glomerular haematuria often with persistent proteinuria of a variable degree. This chapter reviews the pathology, pathogenesis, prognosis, and treatment options for IgA nephropathy.

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