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Membranous nephropathy 

Membranous nephropathy
Membranous nephropathy

Claudio Ponticelli

, Richard J Glassock

, and Patrizia Passerini

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date: 15 June 2021

Primary membranous nephropathy (MN) is an auto-immune glomerular disease which is characterized histologically by uniform thickening of the glomerular capillary due to the presence of subepithelial immune complexes. The lesion of MN should be regarded as a ‘pattern of injury’ as it is not always possible to distinguish a primary from secondary form of MN by morphology alone. MN is a frequent cause of nephrotic syndrome (NS) in adults. It may have a tendency for spontaneous remission in some subjects while other patients show persistent proteinuria and slow progression to end-stage renal disease (ESRD). Those patients with severe and unremitting NS may also suffer from disabling and even life-threatening extra-renal complications, such as thrombo-embolic events and cardiovascular disease. This chapter shows the pathology, treatment options, and risk factors for primary MN.

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