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Managing behavioural and psychological symptoms in Alzheimer’s disease 

Managing behavioural and psychological symptoms in Alzheimer’s disease
Managing behavioural and psychological symptoms in Alzheimer’s disease

Philippe Robert

, Elsa Leone

, Hélène Amieva

, and David Renaud

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date: 25 February 2021

This chapter focuses on the behavioural and psychological symptoms of Alzheimer's disease and the different approaches clinicians can take in their treatment of the condition. The behavioural and psychological symptoms are defined as primary manifestations of cerebral dysfunction, and appear specifically as a result of damage to a system or circuit such as the limbic system or the cortico-subcortical circuits. During the progression of Alzheimer’s disease, the presence of at least one BPSD is common and can vary, depending especially on the severity of the dementia-related syndrome at the time of diagnosis. Management of BPSD should preferentially be based on non-pharmacologic approaches first. Pharmacologic treatments should constitute second line treatment and are to be prescribed only after assessment of the individual risk:benefit ratio.

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