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Atypical presentations of Alzheimer’s disease 

Atypical presentations of Alzheimer’s disease
Atypical presentations of Alzheimer’s disease

Matthew Jones

and Jennifer Thompson

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date: 22 January 2021

Alzheimer’s disease usually presents in older age with progressive episodic memory loss. Atypical presentations of Alzheimer’s disease occur and involve non-amnestic and early-onset forms of the disease. Posterior cortical atrophy (PCA) and logopenic progressive aphasia (lvPPA) are two well-described syndromes that are most commonly due to atypical presentations of Alzheimer’s disease. PCA is a higher-order disturbance of vision whilst lvPPA is characterized by hesitant speech with word-finding difficulties and problems with repetition of words and phrases. Early-onset Alzheimer’s disease presents before the age of 65 and typically consists of a constellation of progressive cortical deficits including language disturbance, apraxia, visuospatial deficits, and poor working memory. Alzheimer’s disease may rarely be inherited because of an autosomal dominant mutation in one of three genes (PSEN1, PSEN2, and APP). Recognition and accurate diagnosis of these atypical forms is vital to ensure patients receive the most appropriate care and treatment.

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