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Heart transplantation 

Heart transplantation
Chapter:
Heart transplantation
Author(s):

Finn Gustafsson

, and Kasper Rossing

DOI:
10.1093/med/9780198759935.003.0010_update_001

Update:

Small amends throughout

Updated on 29 July 2020. The previous version of this content can be found here.
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date: 27 February 2021

Heart transplantation remains the treatment of choice for end-stage heart failure refractory to conventional treatment. Long-term outcome is excellent, and median survival currently exceeds 13 years. The main causes of death late after transplantation are cardiac allograft vasculopathy and cancer. Medical therapy after transplantation is complex, including immunosuppressive therapy to reduce the risk of graft rejection and prophylaxis against viral and protozoal infections, as well as adjunctive therapy to treat common comorbidities, for instance hypertension. Pharmacological therapy of comorbid conditions requires specific consideration to clinically important interactions with immunosuppressive drugs.

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